Can proton pump inhibitors cause vitamin B12 deficiency?
When proton pump inhibitors are taken for more than two years, it has been associated with depletion of vitamin B12.
Last updated on 12 Dec 2024
One can suspect of having vitamin B 12 deficiency if you are constantly feeling lethargic and having nausea along with stomach upset.
It is not very dangerous, however, excess amounts of vitmain B12 can cause headaches and nausea.
A serum vitamin B12 level between 200 pg/mL and 900 pg/mL is considered normal, however, values ranging between 300 to 350 pg/mL is recognised as a marker for a desirable status in the elderly.
Deficiency of vitamin B12 is associated with multiple pregnancy related complications such as spontaneous abortion, recurrent pregnancy loss, small for gestational age (SGA), low birth weight (LBW), intrauterine growth restriction (IUGR) and overall weakness.
They are an integral part of B complexes. The key difference between vitamin B3 and B12 is that vitamin B3 is important in controlling cholesterol and triglyceride levels in our blood, whereas vitamin B12 is important as a cofactor in DNA synthesis for both fatty acid and amino acid metabolism.
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