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MPL (Myeloproliferative Leukemia), Gene Mutation in Mayuri Nagar Welfare Association, Hyderabad

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  • MPL (MYELOPROLIFERATIVE LEUKEMIA), GENE MUTATION

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blood sample
SAMPLE TYPE

BLOOD

Gender
GENDER

Both

users
AGE GROUP

7 years & above

The myeloproliferative (MPL) gene regulates the number of blood cells produced in the bone marrow. It provides instructions to the body for making thrombopoietin receptor protein, which helps the body promote cell growth and division.

A myeloproliferative gene disorder causes blood cells, such as red blood cells, white blood cells or platelets, to grow abnormally in the bone marrow. This may cause anaemia, infections, fatigue, bleeding problems, and other symptoms. Myeloproliferative gene disorder are not generally noticed until years after the onset because this disorder builds up slowly.

Specifications of MPL Gene Mutation Test

The MPL gene mutation test includes a complete blood count test that measures the levels of various cells such as red blood cells, white blood cells, and platelets in your blood. 

Since leukaemia often starts in the bone marrow, checking the bone marrow for leukaemia cells is one of the primary aspects of testing. Bone marrow samples are collected from two different tests that are conducted at the same time:

  • Bone marrow aspiration
  • Bone marrow biopsy
  • The samples are then examined for abnormal cells.

People aged 45-50 are at higher risk of MPL gene mutation. High radiation doses may further increase the risk. Men fall higher on the risk graph for this disease. 

It is recommended to get yourself tested at the first signs of symptoms. If left untreated, it could be life-threatening. 

Who Should Get Tested? 

One of the initial signs of myeloproliferative gene disorder is an enlarged spleen. You will likely get tested for MPL leukaemia if you have an enlarged spleen. This condition requires immediate attention and care when diagnosed. People who often have shortness of breath, fatigue, loss of appetite, infections, and persistent bleeding from minor cuts also need to take the test.

Medically reviewed by Dr. Sanjaya Mishra, Radiation Oncology, Apollo Hospitals Old Sainik School Road, Bhubaneswar.

faqFrequently Asked Questions (FAQs)

What is myeloproliferative gene disorder?

Myeloproliferative gene disorder impacts the blood cells, which consists of red blood cells, white blood cells and platelets. When these blood cells grow abnormally in your bone marrow, it causes myeloproliferative gene disorder. There are several types of this gene disorder, depending on what kind of blood cells the body produces extensively. It usually affects only one specific type of blood cell.

What are the different types of myeloproliferative gene disorders?

Myeloproliferative gene disorder are of several different kinds, such as: Chronic myelogenous leukaemia- This leads to the abnormal growth of one kind of white blood cell, called granulocytes, in bone marrow  Chronic eosinophilic leukaemia- When bone marrow produces abnormal growth of one type of white blood cell called the eosinophils Chronic neutrophilic leukaemia- This cancer causes an overabundance of granulocytic white blood cells or neutrophils Polycythemia vera- This health condition causes bone marrow to produce excessive red blood cells, often leading to gene mutation Essential thrombocythemia- This condition makes the blood too sticky due to excessive production of platelets, which can lead to clogged blood vessels, stroke or heart attack Primary myelofibrosis- This causes the bone marrow to overproduce collagen, which limits the marrow’s ability to make any other blood cells

What are the primary causes of myeloproliferative gene disorder?

Myeloproliferative gene disorder does not have one single known cause. That said, this gene mutation in your bone marrow cells can be attested to some of the following factors: Having a specific virus Being surrounded by certain toxic chemicals Radiation exposure Past family history

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The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results