CD55 (Pnh Marker) in Chennai Central Railway Police Station, Chennai

A rare blood disorder known as paroxysmal nocturnal haemoglobinuria (PNH) occurs due to genetic mutations or inheritance. PNH falls under the category of both genetic and autoimmune disorders. As a result of this condition, your immune system starts attacking the RBCs in your system and breaks them down.

The main reason behind the breakdown of RBCs is the lack of a protein, which acts as a protective barrier to avoid this destruction. A PNH marker test is crucial because this disorder can take place at any age. So, it is safer to be aware of systemic behaviour and take preventive measures.

A PNH quantification test is necessary because there is no specific symptom for this type of haemoglobinuria. It affects every patient differently depending on the exceptions in their respective systems. While some patients may have minor symptoms, others might suffer from severe ones. PNH may also affect the WBCs and platelets that fight infections and blood clotting, apart from RBCs.

A PNH marker test helps in the early diagnosis of the condition because nearly 30% of people are prone to this rare disorder. It is an acquired disorder due to a variant of the PIGA gene. The surface proteins on RBC are absent, making it hard for your immune system to recognise its blood components. Hence, haemolysis is a common symptom of PNH that might have adverse effects on the body.

A PNH marker test helps diagnose the condition and classify the type of PNH in each person. Furthermore, the CD55 test helps in understanding the disease's progression and monitors the treatment's effect.

A CD55 test is a sensitive method to detect PNH in an individual. The technique is known as flow cytometry and detects the rare clones of PNH.

As far as symptoms are concerned, many people opt for a PNH quantification test at a later stage due to common symptoms. Here are some symptoms that you can observe before undergoing a CD55 test:

• Dark coloured urine due to the presence of haemoglobin, bin especially the in early morning
• Anaemia due to premature haemolysis
• Blood clotting in veins
• Pale or yellowish skin
• Easily noticeable bruises on the skin
• Breathlessness, fatigue, and muscle pain
• Frequent headaches with seizures in rare cases
• Difficulty in swallowing the food
• Consistent pain the in the belly
• Erectile dysfunction in men due to lack of proper blood supply throughout the body
• Tingling sensation in toes and feet
• Painful swelling near some veins due to blood clot
• Sore or swollen limbs due to lack of proper oxygen supply and blood supply
• Ulcers and bleeding the in stomach

Apollo 24|7 offers a CD55 test that requires a peripheral blood sample and quickly identifies the lack of GPI-linked antigens in the blood. This test is available for ₹ 1980 with the results delivered to you within 72 hours.