SRY Testing By Fish in Pragathi Enclave, Hyderabad

The Sex Determining Region Y (SRY) gene codes for a protein responsible for developing male characteristics in the foetus. This gene is present on the Y chromosome and helps find gender differentiation abnormalities in the foetus.

SRY testing by Fluorescence In-Situ Hybridisation (FISH) method determines the deletion or mislocation of this gene. Abnormalities in the SRY gene test can give insights about the abnormal gene in parents.

Gender differentiation abnormalities can lead to various problems in a child since the issue occurs at the genetic level. Early diagnosis can help prepare for the condition and take the necessary steps.

The FISH technique is an accurate methodology for genetic tests. Many paediatricians and genetic counsellors order complete karyotyping that determines the structure of each chromosome present in the individual. A paediatrician can also advise microarray testing as an alternative to SRY gene test and karyotyping for detailed information.

The SRY protein has a specific pattern in every individual, and it is responsible for the development of male gonads. Also, the gene prevents the development of female characteristics in the foetus. This gene is also known as the testis-determining factor.

Who Should Get Tested?

This routine test allows the parents and pregnant woman to understand if the baby has any genetic disorder related to gender differentiation. It can detect Swyer syndrome, testicular development disorder, and other problems like gene translocation.

The displacement of the gene to an X chromosome causes the ovotesticular disorder. To manage such rare conditions effectively, early diagnosis is essential. There are several treatments like hormone therapy and psychological counselling available for such patients. 
 

Medically reviewed by Dr. Sushmita Prakash, Obstetrics and Gynaecology, Apollo Hospitals Sector 26, Noida