CALR Mutation Detection in Ganguly Bagan, Kolkata
No preparation required
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Test(s) Included (1)
- CALR Mutation Detection
1 test included
About
BLOOD
Both
7 years & above
The CALR mutation detection test is a diagnostic test that is primarily used to identify mutations in the CALR gene, a gene that is responsible for making a protein called calreticulin. This protein ensures the correct folding of new proteins in the body and maintains appropriate calcium levels in cells. However, CALR gene is also associated with certain blood disorders such as myeloproliferative neoplasms (MPNs).
MPNs are a group of disorders in which the bone marrow produces too many blood cells, leading to an increased risk of blood clots, bleeding, and other complications. CALR mutations are found in a significant proportion of MPN cases, particularly those that do not have mutations in the JAK2 or MPL genes. The CALR mutation detection test uses molecular techniques to detect specific mutations in the CALR gene, which can help to diagnose MPNs and inform treatment decisions.
In addition to diagnosing MPNs, the CALR mutation detection test is also helpful in providing information about a patient’s prognosis. Your healthcare provider will assist you with appropriate CALR mutation treatment based on the results. A positive result is a common indication of myeloproliferative neoplasm (MPN). Your healthcare provider may even advise other tests like bone marrow biopsy to determine the type of MPN and its severity.
The CALR mutation is commonly found between 20-25% of people with essential thrombocythemia (ET) and the same division of people with primary myelofibrosis (PMF). It is also rarely found in people with chronic myelomonocytic leukaemia (CMML), myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML), and chronic myeloid leukaemia (CML).
As a general rule, you must get yourself tested for CALR mutation detection when you detect abnormal test results on a Complete Blood Count (CBC). It may also be prescribed if your healthcare provider suspects that you have a bone marrow disorder. At Apollo 24|7, you can book the CALR mutation detection test and get your sample collected. To make it easier for you to understand, here are some reasons why you must opt for this CALR mutation detection test:
If you have significantly increased haemoglobin levels
- Increased levels of red blood cells
- Clinical signs and symptoms suggest an MPN
Frequently Asked Questions (FAQs)
Is there any preparation needed for the test?
When is the CALR mutation detection test needed?
Are there any symptoms of CALR mutation detection?
What do the test results mean?
Is the CALR mutation hereditary?
Is there anything else I should know?
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The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results