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Beta Crosslaps in Lucknow

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  • BETA CROSSLAPS

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About

blood sample
SAMPLE TYPE

BLOOD

Gender
GENDER

Both

users
AGE GROUP

7 years & above

The human body constantly undergoes the process of formation and resorption during which bones are remodeled. Around 90% of a bone's organic matrix comprises Type I collagen. During the bone remodeling process, osteoclast cells release a mixture of neutral and acidic enzymes that break down the collagen into molecules, including C-terminal telopeptide (CTx).

As bones age, the amino acids present in CTx change their chemical composition from Alpha to Beta. When that occurs, the bone remodeling process releases Beta-CTx into the bloodstream, which is indicative of Type I collagen degradation.

Increased concentrations of Beta-CTx in the blood indicate an overactive bone remodeling process in the body. Such abnormalities in bone turnover can result in:

  • Change in skeletal mass and bone density
  • Bone deformation

Some common conditions that are associated with unusual bone turnover include the following:

  • Hyperthyroidism
  • All forms of hyperparathyroidism
  • Osteomalacia (softening of the bone)
  • Paget disease
  • Multiple myeloma (Plasma Cell Cancer)
  • Bone metastasis (Spread of cancer cells to a bone)

Besides these bone-related diseases, post-menopausal osteopenia (loss of bone density after menopause) and osteoporosis (brittle bones) can also lead to an overactive resorption process.

Bone resorption can also occur around a patient’s mouth or jaw. Some common symptoms of this particular type include the following:

  • Swelling of gums
  • Pain in the crown, root or internal space in a tooth
  • Brittle teeth 
  • Gum discolouration

A Beta Cross Laps (B-CTx test) helps to determine a subject’s bone turnover rate. Specific markers discovered during the test can help detect bone diseases or be used to supplement tests for bone density.

The test is performed through a Roche Cobas 6000 e601 analyzer. Labeled with ruthenium, the patient’s specimen reacts to form a complex. Voltage is then applied to the electrode, after which it's measured against a calibration curve. That measurement reveals the amount of B-CTx present in the patient specimen.

A B-CTx test can also be used to outline treatment options for bone-related diseases. In the case of adults, the test can be used for the following:

Monitoring response to anti-resorptive therapies such as hormone replacement and bisphosphonates
Measuring the effectiveness of drug dosage

For children, the test can be used to detect and manage the following conditions:

  • Metabolic bone disorders
  • Paget disease
  • Rickets
  • Secondary osteoporosis

With the help of a B-CTx test, specific bone turnover abnormalities can be treated with timely intervention. Consistent monitoring of urine and serum markers can be used to determine any changes in a patient’s subsequent bone turnover rate.

An effective way to keep bone resorption under check is to exercise regularly. It's also essential to avoid high doses of Vitamin D supplements. Previous studies have indicated that excessive Vitamin D can lead to an accelerated turnover rate. To manage this, patients must moderate Vitamin D intake with calcium supplements.

In the case of facial bone breakdown, it’s possible to minimize the effects of dental implants. In extreme cases, bone grafting may be necessary.

Apollo 24|7 offers a comprehensive B-CTx test that can be a diagnostic tool to determine any pre-existing bone-related issues in the patient.
 

Medically reviewed by Dr. Kosygan K P, Orthopaedics, Apollo Hospitals Greams Road, Chennai.

faqFrequently Asked Questions (FAQs)

When does bone resorption begin?

From 25 to 50 years of age, bone density usually remains stable with a balance between new bone formation and bone breakdown. Once an individual reaches the age of 50, the breakdown process outpaces the formation of new bone. This is particularly prevalent in women during menopause.

Is bone resorption a preventable condition?

The breakdown of bones is a necessary and natural process of the human body. However, acceleration in this process can lead to several complications. It's recommended to moderate Vitamin D intake with calcium supplements to avoid any bone turnover abnormalities. Regular exercise is also helpful.

What can abnormal bone turnover lead to?

Accelerated resorption can lead to the following: Decrease in bone mass and density Change in skeletal shape and deformation Brittle bones, leading to increased fracture risk

When should you opt for the test?

All adults are recommended to get a B-CTx test done regularly. Yearly checkups can be beneficial and predict the early onset of bone-related diseases.

Who can be considered at-risk for abnormal bone turnover?

Women undergoing menopause or post-menopause are at a higher risk of incurring an abnormal bone turnover rate. This is due to the reduced production of estrogen in post-menopausal women. Such women should consult a doctor and get a test done to avoid any complications later on. Adults over the age of 50 are also at-risk individuals.

What preparatory measures can you take before undertaking the test?

In addition to a 12-hour fast, patients must avoid any vitamin or dietary supplements that contain biotin (B7 Vitamin). Biotin is commonly found in hair, nail and skin care multivitamin supplements. Intake of such supplements before the test can affect the test results.

Why should Apollo be your preferred healthcare partner?

  • 40 Years of legacy and credibility in the healthcare industry.
  • NABL certified multi-channel digital healthcare platform.
  • Affordable diagnostic solutions with timely and accurate test results.
  • Up to 60% discount on Doorstep Diagnostic Tests, Home Sample Collection.
  • An inventory of over 100+ laboratories, spread across the country, operating out of 120+ cities with 1200+ collection centers, serving over 1800+ pin codes.

The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results