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Anti Soluble Liver Antigen (SLA) in Hyderabad

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  • ANTI SOLUBLE LIVER ANTIGEN (SLA)

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About

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SAMPLE TYPE

BLOOD

Gender
GENDER

Both

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AGE GROUP

7 years & above

Autoimmune diseases are tricky because your immune system starts attacking different body parts. Autoimmune hepatitis (AIH) is a disorder that can cause liver inflammation and harm the liver cells.

When left untreated, autoimmune hepatitis can cause permanent scarring or cirrhosis of the liver and eventually can cause permanent liver failure.

This fatal situation, however, can be avoided by early detection and treatment. Although there is no cure for autoimmune hepatitis, preventive measures can prolong the patient’s life. Hepatitis C is a disease that is linked with many autoimmune disorders.

A few common autoimmune disorders include:

  • Cryoglobulinemia: Proteins in the blood clump together and thicken the blood in lower temperatures, preventing blood circulation. 
  • Immune Thrombocytopenic Purpura: Also known as idiopathic thrombocytopenic purpura, this disorder causes excessive bruising and bleeding because of low platelet count. 
  • Rheumatoid arthritis: A chronic inflammatory disease that occurs in the linings of the joints and is extremely painful. This disorder causes erosion and deformity to the joints. 
  • Sjogren’s syndrome: This disorder targets the saliva and tear glands and causes dry eyes and mouth. It is associated with non-erosive arthritis. 
  • Systemic Lupus Erythematosus: Also known as lupus, this chronic disease is the most common disorder associated with hepatitis C and causes inflammation in your connective tissues. 
  • Thyroid disorders: Hypothyroidism and hyperthyroidism are both results of this disorder. The most common type of this disorder is Hashimoto’s thyroiditis.

Anti Soluble Liver Antigen (SLA) Test or Anti-SLA test helps determine the antibody levels in the blood to confirm autoimmune liver diseases. This blood test is highly effective in detecting autoimmune hepatitis and can be ordered through Apollo 24|7 website. Since hepatitis C is caused by the hepatitis C virus (HCV), this test is also helpful in detecting HCV infections.

During the Anti-SLA test, the quality and quantity of the antibodies are tested to determine the presence of autoimmune liver diseases. This is done against a soluble liver antigen or SLA. The anti soluble liver antigen or SLA test can only detect whether someone is suffering from severe diseases and autoimmune liver disorders.

Not much preparation is required for the anti soluble liver antigen or anti-SLA test. But you must inform your doctor about any medication you are undergoing during the test. Depending on this, your doctor may advise you to stop using the medication the night before the test sample collection. 
 

faqFrequently Asked Questions (FAQs)

What is Anti Soluble Liver Antigen (SLA)?

Anti Soluble Liver Antigen (SLA) is an antibody in the body of individual suffering from AIH. This antibody is detected in almost 30% of the patients who suffer from the disease. Among these, 15% of cases only show the occurrence of the Anti Soluble Liver Antigen (SLA) antibody. Therefore, the Anti Soluble Liver Antigen (SLA) test is a viable method for detecting autoimmune hepatitis.

What is an SLA antibody?

Soluble liver antigen (SLA) antibodies are usually directed against normal tRNA protein that causes UGA suppression. This is most prevalent in cases of autoimmune hepatitis (AIH). However, in rare cases, these are the only autoantibodies detected in the blood sample of patients with autoimmune hepatitis.

What is meant by liver antigen?

The antibodies produced in the presence of soluble liver antigens are a great way to detect severe cases of AIH. For instance, the liver pancreas antigen, anti-SLA/LP, is an excellent marker for detecting AIH in 10-30% of patients. Other serological markers for liver antigen include anti-SLA and atypical pANCA.

How can autoimmune hepatitis occur?

Usually, autoimmune hepatitis is a frequent cause of infection, caused by Epstein-Barr virus or herpes simplex virus, and measles. It has also been noticed that the disorder is associated with hepatitis C, B, and A types. It is also possible to pass down the autoimmune liver disorder to the next generation.

Which antibodies can be found in autoimmune hepatitis patients?

Usually, antinuclear autoantibody and F-actin reactive smooth muscle autoantibody are the two commonly found antibodies in onset type 1 autoimmune hepatitis. This appears in almost 60% of cases of autoimmune liver disorder. In the other 15-20% of cases, the SLA/LP antibodies mark their presence. LKM-1 and LC-1 are two types of autoantibodies found in juvenile-onset type 2 autoimmune hepatitis cases.

What are type 1 and type 2 autoimmune hepatitis?

Autoimmune hepatitis or AIH can be of two primary types: type 1 and type 2. Type 1 AIH is the classic type of autoimmune hepatitis. It is usually diagnosed during adulthood. On the other hand, type 2 autoimmune hepatitis disorder is noticed during childhood. However, the treatment for both types of AIH is similar.

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The information mentioned above is meant for educational purposes only and should not be taken as a substitute to your Physician’s advice. It is highly recommended that the customer consults with a qualified healthcare professional to interpret test results