Anca Profile (MPO & PR3)

The ANCA Profile test checks your blood for Antineutrophil Cytoplasmic Antibodies (ANCAs). Your immune system produces proteins called antibodies to fight external invaders like germs and viruses.

However, ANCAs mistakenly target healthy neutrophils, a kind of white blood cells that can lead to Autoimmune Vasculitis.

Blood vessel swelling and inflammation are brought on by Autoimmune Vasculitis. Blood vascular inflammation can result in significant medical issues depending on which physiological systems and blood vessels are impacted.

ANCA exists in two primary varieties. Each one focuses on a distinct protein found within white blood cells:

• pANCA, which goes after the MPO (Myeloperoxidase) protein  
• cANCA, which attacks the PR3 (Proteinase 3) protein

Whether you possess one or both kinds of antibodies is determined by the ANCA Profile test offered by Apollo 24|7. The package includes two tests, one for pANCA and the other for cANCA. This can assist your doctor in identifying and treating your illness.

The most popular method for determining if you have Autoimmune Vasculitis is to undergo an ANCA Profile test. This condition exists in various forms. Each variety affects various blood vessels and regions of the body, but they all result in blood vessel enlargement and inflammation. The following are examples of Autoimmune Vasculitis:

• GPA: Wegener's disease, popularly known as Granulomatosis with Polyangiitis (GPA). It can have an impact on the kidneys, lungs, and sinuses 
• MPA: Miniature polyangiitis (MPA) is a condition that may impact the neurological system, skin, lungs, kidneys, and other body organs 
• EGPA: Formerly known as Churg-Strauss syndrome, Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a condition that typically affects the lungs and the skin 
• PAN: Polyarteritis Nodosa is a condition that frequently impacts the central nervous system, kidneys, heart, and skin

If you exhibit signs of Autoimmune Vasculitis, your doctor might recommend an ANCA Profile test. These signs include:

• Fever  
• Exhaustion  
• Aches in the joints or muscles
• Weight loss

Your symptoms may also impact one or more particular body organs. Organs frequently impacted, and the indications they bring on are as follows:

• Eyes: Redness, haziness, and blindness 
• Ears: Tinnitus (ringing sound in the ears), loss of hearing 
• Sinuses: Runny nose, bleeding from the nose, and sinus pain 
• Skin: Rashes, blisters, or ulcers, a particular kind of deep sore that heals slowly or keeps recurring 
• Lungs: Coughing, breathing issues, and chest pain 
• Kidneys: Frothy urine and blood in the urine, which are symptoms of urine protein contamination 
• Nervous system: Stinging and numbness in different body parts

A tiny needle will be used to extract a blood specimen from a vein in the arm during the ANCA Profile test. Following the insertion of the needle, a minute quantity of blood will be collected in a vial or test tube. When the needle is inserted, you can feel a little discomfort.