HLA-C Typing

HLA – C Typing test is a comprehensive genetic test that is aimed at detecting specific genetic markers of the immune system present in individuals. These markers are present on the surface of white blood cells called human leukocyte antigens or HLA. The human leukocyte antigen (HLA) gene complex is responsible for encoding the proteins present on the surface of white blood cells and their role in immunological processes. HLA-C molecules are important because they play a crucial part in the immune response against viral infections and are also linked to autoimmune diseases.

The HLA-C Typing test is primarily used to diagnose conditions or diseases that are associated with the HLA-C genes. These genes are associated with several autoimmune diseases such as psoriasis, rheumatoid arthritis, ankylosing spondylitis, and celiac disease. Individuals with inflammatory bowel disease may require an HLA - C typing test for diagnosis.

The HLA-C Typing test is also important for organ or tissue transplantation procedures because it ensures that the donor and the recipient have compatible tissue types and whether or not the tissue will be accepted by a recipient's body. If the donor and recipient are not compatible, the recipient's immune system will likely reject the transplant, leading to organ failure or death.

Symptoms of Organ Failure

HLA-C Typing is not a diagnostic test for any specific condition or disease. However, it is important for organ transplantation as it detects genetic markers to ensure that the donor and recipient have compatible tissue types. The symptoms of organ failure vary depending on the organ affected. Some of the symptoms associated with organ failure include:

• Chronic joint pain
• Fatigue
• Inflammation
• Swelling
• Stiffness
• Digestive issues
• Abdominal pain
• Diarrhoea
• Rectal bleeding

Sample Procurement Method for Conducting HLA-C Typing Test

The HLA-C Typing test requires a blood sample from the patient. A qualified lab technician will take a sample from a vein in your arm using a sterile needle and syringe. The procedure is simple and quick and takes about 5-10 minutes. No special preparation or fasting is required prior to the test and patients can resume their daily activities immediately after the blood draw. Once the sample has been taken, it will be sent to the laboratory for testing.

The collected blood sample is analysed using polymerase chain reaction (PCR) technology to detect the specific genetic markers on the surface of white blood cells called human leukocyte antigens or HLA. PCR works by amplifying small amounts of DNA sequences to detect variations in the genetic code associated with HLA-C alleles. The test results include information on which specific alleles are present in the patient's DNA. The results are typically available within eight days.

Treatment Options

The HLA-C Typing test is not a diagnostic test for any specific condition or disease and it does not provide a diagnosis on its own. However, it is important for organ transplantation as it detects genetic markers to ensure that the donor and recipient have compatible tissue types. These gene markers may be associated with certain conditions or diseases. Once the results are obtained, a healthcare professional can use them to provide an accurate diagnosis and suggest appropriate treatment options.

If an individual tests positive for an autoimmune disease, treatment will depend on the specific condition diagnosed. Treatment may include medications such as NSAIDs, DMARDs, steroids, and biological agents, lifestyle changes, physical therapy, and surgery in severe cases. For transplant recipients, the results of the test will determine compatibility with the donor organ.

Benefits of Early Diagnosis:

Early diagnosis and detection with the HLA-C Typing test is essential for most autoimmune diseases as it allows for timely treatment and management of symptoms. In the case of organ transplantation, early diagnosis through an HLA - C typing test can help improve the success rate of the transplant procedure.

How to Book HLA – C Typing Panel Test on Apollo 24|7

Booking an HLA – C typing test is easy on Apollo 24|7. You can visit the website or download the Apollo 24|7 app and select the HLA – C typing test from the list of available tests. Select a convenient time slot for the blood sample collection at your nearest Apollo clinic and pay online. You can expect to receive your test results within 8 days online.