I'm really worried about my uncle, he's 62 and has IHD. He's dealing with this massive left-sided pleural effusion and he's been in Railway hospital Bhaykhala with an ICD in place. We've been seeing a daily output of about 350-400ml of pleural fluid that's yellowish with a slight reddish tinge. The doctors at Tata hospital did two cytology tests for malignant cells and both came back negative. A PET-CT scan showed a small extra pleural nodule about 11x7mm at the pulmonary confluence, needing histopathological correlation, and the SUV max is 4.3. They've tried Augmentin and Magself Cefoperazone, but the fluid output hasn't changed. They've recommended a biopsy of the nodule. I'm just wondering if there are any other treatment options we could consider.